I see you have already tried lowering the dose. Japanese Knotweed- 7000mg per day = 10 capsules. Desperate. Best, Julie. Huzhang (Japanese Knotweed) has been used in traditional Chinese medicine as well as in Japan and Korea for many years. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Hi Melissa, While a lot of debate and study is still ongoing, supplemental and nutritional consumption of Japanese knotweed does seem to hold significant potential. The preparation was standardized to contain resveratrol 40 mg.Zahedi 2013, Topical application of P. cuspidatum extract has been studied in mice for anti-inflammatory effects.Bralley 2008, Wu 2012, Do not use in pregnancy. The root is used extensively in traditional medicine in China, Japan, and Korea, and the young plant parts are eaten as a vegetable. For information specific to the activity of resveratrol, see Resveratrol. Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited. There are no clinical data regarding the use of P. cuspidatum as an antimicrobial agent. P. cuspidatum is a primary source of resveratrol, which is widely available in the United States as a botanical dietary supplement.Hao 2012, Li 2013, Peng 2013, Volatile essential oils are described for the leaves, but the roots are the main plant part used traditionally. Dosage: Just use 1/2 tsp per 10 lbs of body weight. Aside from what the polygonum is doing to treat Lyme, it is also doing other things in the body at the same time. Yes, there are Herxheimer reactions when treating Lyme, but don’t assume that Lyme die off is the cause of every adverse reaction. Resveratrol enhances the activity of a detoxification enzyme called CYP1A1. http://www.earthmedicine.ca/lyme-disease.html#Protocol, Thank you for your time today. We comply with the HONcode standard for trustworthy health information -. “Healing Lyme”) Thanks! This information relates to an herbal, vitamin, mineral or other dietary supplement. No hemolysis, agglutination reaction, or systemic anaphylaxis/skin allergy was found in tests conducted in rabbits.Peng 2013. Do not use if pregnant, during breastfeeding or attempting to get pregnant. The LD50 of emodin and polydatin is 250 and 1,000 mg/kg, respectively. 3 Tbs 4x a day would equal over 50 grams of the powder. Japanese Knotweed Root is an angiogenesis modulator, stimulating the formation of new blood vessels and the healing of damaged ones in areas such as burned skin, but also stops the development of new vessels and blood flow in areas where it should not occur, … A Tbs is 5.6 grams. Gum disease (gingivitis).Developing research suggests that a root extract of knotweed might be useful as a mouth rinse to treat gingivitis. we tried half a capsule, and it was too much, I tried again, giving him less than half a capsule, and it is still to much. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. *Please note the recommended dosage may differ from other sources. contemplating putting her down. She has been taking this dosage for two months, and is under the care of a practitioner. Suggested dosage: 20-40 drops (a half to full dropperful), 1-3 times per day. Green Dragon’s bottle of LB Core Protocol say they base their formula on your book. So to be clear, is it 1 or 2 ‘500mg’ tablets of GDB’s Japanese Knotwood per day? Does anyone else have a source of polygonum cuspidatum? . Discontinue the use of Japanese knotweed 10 days prior to surgery. Each individual is unique and what works for one person may not work for another. Nature 410, 227–230 (2001). Can someone please give me an estimated dose for her. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. This information is not specific medical advice and does not replace information you receive from your health care provider. I have a package of the Nuherbs Japanese Bushy Knotweed Root, 1lb Bulk Herb. Studies conducted in the 1980s and 1990s in rodent models of hyperlipidemia showed decreased total cholesterol, as well as decreased triglycerides and low-density lipoprotein.Peng 2013 Oral polydatin from P. cuspidatum showed similar results in rabbits and hamsters.Du 2009, Xing 2009. This information should not be used to decide whether or not to take this product. Studies in rats and mice have shown antioxidant properties of P. cuspidatum that are generally attributed to the chemical constituents of resveratrol, polydatin, piceatannol, and anthraquinones and stilbenes.Kim 2010, Peng 2013, Piotrowska 2012, Zhang 2012 Carbon tetrachloride–induced liver injury and induced acute cerebral ischemia were reduced by oral extracts of P. cuspidatum.Kim 2010, Zhang 2012 In models of vascular dementia and Parkinson disease in rats, P. cuspidatum extract and polydatin administered orally resulted in improved cognitive and behavioral measures and increased antioxidant capacity in the relevant tissues.Li 2012, Wang 2011. Medically reviewed by Drugs.com. Learn how your comment data is processed. I have been giving it to my adult son, a lot of it…curious what he was experiencing that was so bad to stop? For example, in Chinese medicine, herbs are prescribed based on the patient’s presentation, and many people would not be given this herb. She takes 4/day. BioPure Japanese Knotweed from Polygonum cuspidatum, also known as Japanese Knotweed, or by the Mandarin Chinese name of Hu Zhang, is native to Asia, and is a robust perennial in the Buckwheat family. *This statement has not been evaluated by the Food and Drug Administration. Because of the plant's spreading rhizomes, P. cuspidatum is grown commercially as a major source for resveratrol production (see Resveratrol monograph), while also being considered a noxious, invasive class B or C weed in certain US states.Chen 2013, Peng 2013, USDA 2013, At least 100 prescriptions using the root exist in the Pharmacopoeia of the People's Republic of China to treat bronchitis and cough, gonorrhea, inflammation, infection, jaundice, hyperlipidemia and hypertension, menopausal symptoms and amenorrhea, and skin burns. Most of the effects of Japanese Knotweed can be traced back to either the stilbenes (resveratrol) or the anthraquinones (emodin) for the circulatory and gastrointestinal help, respectively. Chilly April days have been spent harvesting and processing large, gorgeous, deep orange, potent, Japanese Knotweed rhizomes, collected from a select and pristine location in the heart of Vermont. we started with one tablet, it was to much. Your email address will not be published. Is it really unsafe as some say? Why are we preparing japanese knotweed from the fresh herb when it grows as a noxious weed in some places. Moldenke, Fallopia japonica (Houtt.) In people with certain genetic variations of this enzyme, taking resveratrol will cause them to feel toxic and ill. There’s no way for me to know for sure what’s going on, but I think it’s important to respect the body and what it’s telling you. It is cultivated in those countries and in the US, and is propagated by seeds or the root. The Hawthorn’s been a God send. Cat’s Claw vine bark – 500 mg. (Uncaria tomentosa) – wildharvested – Peru 1. Clinical evidence on which to base dosing guidelines is lacking. var. Hi Patty, Andrographis herb – 430 mg. (Andrographis paniculata) – organic – India If you are interested in learning about the full protocol please invest in the full book. Select one or more newsletters to continue. Ingredients: Old-growth, wild-harvested Japanese Knotweed rhizomes; grain alcohol, Vermont spring water. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Interfere with the Chinese 30 gram … 1 to replace the expertise and care of a health... I see you have already tried lowering the dose would be 1/3 of a practitioner with regards to?! To eastern Asia 20-40 drops ( a half to full dropperful ), 1-3 times per?! 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